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p53 p53 plays a crucial tumor-suppressive role in regulating cell cycle arrest, apoptosis, and DNA repair

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Table 1 summarizes the clinical characteristics of the 36 included subjects

Results We observed that PC-12 cells treated with high-dose corticosterone at 400 M had decreased cell viability, reduced endogenous antioxidant enzyme activities, disrupted mitochondrial function, and increased oxidative stress and apoptosis