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Radiation-induced DNA damage is sensed by the kinases ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related protein (ATR), which activate downstream proteins to initiate the DNA damage response (reviewed in Maier et al., 2016)

These findings provide evidence of the high safety profile of this type of treatment intervention

541 A deeper exploration of mito-nuclear communication is essential for understanding the pathogenesis and heterogeneity underlying mitochondrial diseases

An "RNA interference agent" as used herein is defined as any agent that interferes with or inhibits the expression of a target biomarker gene by RNA interference (RNAi)

Detoxification : It aids in the detoxification of harmful substances, including heavy metals and environmental toxins