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Among the 25 genes, Slco1a4 , Akr1c19 , and Cyp4f15 are the most downregulated at the RNA level, with Slco1a4 being involved in the transport of bile acids and other monocarboxylic acids ( Figure 4C )

Its ability to scavenge reactive oxygen species (ROS) is especially critical given the CNSs high metabolic activity and inherent susceptibility to oxidative stress-induced cellular injury

Using SH-SY5Y cells, we demonstrate that A causes an oxidation of both GRX1 and TRX1, and nuclear export of Daxx, a protein downstream of ASK1

10.1126/sciadv.aau6328 277 PandeyD.PatelA.PatelV.ChenF.QianJ.WangY.et al

doi:10.1111/resp.12639 70