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Univariate analysis To define the effect of drug exposure over 4 weeks and 8 weeks of treatment, linear mixed effects models (using the R package nlme 52 ) were fitted on each metabolite adjusting for age, gender, and HRSD 17 scores at baseline with subjects as random variable

If a parent is absolutely against medication, one might try giving a small dose of caffeine (like half a cup of tea which is ~20-30 mg caffeine, plus perhaps an L-theanine supplement) to an older child and see if it helps a bit but again, this is very experimental and should be done with caution and ideally guidance

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CJC-1295/Ipamorelin is the broader protocol, with system-wide effects that accumulate over time

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