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PPAR, peroxisome proliferator-activated receptor alpha

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RC reports consulting and lecture fees from Astellas, Akern, Baxter, B-Braun, Bristol-Myers Squibb, Boehringer Ingelheim, Eli Lilly, Fresenius Kabi, Lionhealth, Nestl Health Science, Novartis, Nutrisens, MSD, Nutricia, Pfizer, Roche, Servier, Takeda, Viatris, all outside the submitted work

Cycling rather than year-round dosing is the norm in non-label research settings because extended daily administration can progressively attenuate GH pulse amplitude through receptor desensitization and because the lipolytic and cognitive benefits plateau well before 52 weeks

Our work shown here now confirms the relevance of K48-K63-branched ubiquitin chains in stress signaling and puts these chains at the center of the lysosomal damage response