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Regarding GPX2 and GCLC, the amino acid modifications found in cetacean-specific glutathione metabolism enzymes optimize redox status and detoxification processes in vascular tissue

Since the late 1990 s, the variety of biologics has continuously increased, encompassing monoclonal antibodies targeting TNF-, integrin inhibitors, and interleukin-12/23 inhibitors

doi: 10.1002/vms3.692 36 PiantoniPWangPDrackleyJKHurleyWLLoorJJ

doi: 10.1186/s12951-021-00892-7 110 LiuW.-J.LiuH.ChenY.-E.YinY.ZhangZ.-W.SongJ.et al

In addition, as this process is reversible and accompanied by a plethora of deregulated enzymes, inhibiting those histone-modifying enzymes activity and regulating its level has been thought of as a potential path for tumor therapy