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Further details regarding the reactions identified by the algorithm are available in Supplementary Data 5

Depletion of luminal Ca 2+ , either during normal cellular physiology or upon addition of pharmacological agents, provokes a rapid and reversible shift towards a more reducing redox state of the luminal [GSH] 2 :[GSSG] ratio [13, 23, 24]

None of these are disqualifying, but together they warrant a pre-purchase email to [email protected] to get key questions answered in writing

Recently, non-covalent inhibitors of SmTGR, presenting antischistosomal efficacy in an animal model of infection, were developed targeting the doorstop pocket (here site S3), which further validates this pocket as a druggable site 96

The helical connection between the parallel sheet unit and the lid domain consists of two short helices (13 and 14) that have the same lengths and orientations in ecGS