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These effects have been particularly relevant in neurodegenerative conditions and metabolic disorders, where mitochondrial dysfunction plays a central role

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4.2 Evidences of CBD to control oxidative stress CBD has been shown to lessen oxidative metabolism in polymorphonuclear leukocytes and nucleus pulposus cells that have been exposed to H 2 O 2 , and numerous research have suggested that CBD possesses antioxidant capabilities (83, 84), and moreover lowers pancreatic cell oxidative stress markers (85)

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380 An experimental model fed with diet lack of prebiotic fiber induces hypertension through inducing deficiency of SCFA production and GPR43/109A signaling, suggesting the underlying mechanisms of dietary fiber