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Hickman et al., 2008, 2013

International journal of molecular sciences , 12 (8), 52135237

Double pathology of vitamin B12 deficiency B12 deficiency leads to the inactivation of methionine synthase (MS), and 5- methyl -THF cannot be utilized, which leads to the stagnation of folic acid cycle (the accumulation of intracellular 5-MTHF increases by 300%) and inhibits purine synthesis