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This difference can be explained by the fact that GBM has a stiff mechanical environment in the brain, which upregulates the expression of Piezo1 ( Figure 2 The expression of Piezo1 can result in mechanical stimulation between glioma cells and promote the occurrence and development of tumors (Hong et al., 2023)

An inability to digest B12 as a result of low levels of intrinsic factor for either genetic reasons or a result of physical damage to the stomach or small intestine can also cause deficiency

7, A to C), and less changes in metabolites including several amino acids, UC metabolites, and pyrimidine synthesis (Fig

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