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However, there are limitations to mouse models including the small size and lack of complexity of the mouse brain ( Statements Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation

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This limitation means that in individuals who are overweight or obese, the occurrence of muscle-depleted obesity (i.e., increased fat accompanied by muscle loss) may be overlooked, thereby leading to inaccurate estimations of body fat percentage (36, 43)