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Description

Once hydroxylated, HIF- proteins have more than a 1,000-fold increase in binding affinity of the von-Hippel-Lindau protein (pVHL), which functions as the recognition component of a multi-subunit RING E3 ligase (VHL complex) containing Cullin-2, Elongin-1, Elongin-2, and Ring-Box 1 (RBX1) (Hon et al

S., Robertson, E

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