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These pathways can be studied in laboratory or preclinical models without automatically proving a treatment effect in humans

NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor

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Non-B12 causes of persistent symptoms with a high result When symptoms persist and the B12 is high, the symptoms may have nothing to do with B12 at all

Vomiting, diarrhea, and constipation also occur with meaningful frequency