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The pathogenesis involves a combination of cell-mediated and humoral immune responses, initiated in genetically predisposed individuals upon exposure to environmental triggers

Cells were resuspended in 1 ml of sterile water and spun down in a tabletop centrifuge at 4 C for 5 min at 3000 x g , and the supernatant was discarded

By inhibiting the pro-fibrotic miR-21 and upregulating the expressions of miR-30 and miR-200, GA can effectively prevent the fibrotic process

Upon ferroptosis induction, NRF2 activation leads to increased CHAC1 expression, contributing to the degradation of GSH and facilitating ferroptotic cell death