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Our data substantially demonstrate methionine-SAM-mtROS axis is the major cause for lipid peroxidation and ferroptosis if cystine is not available

doi:10.3945/ajcn.111.030114

Given these observations, it is plausible that SCOPAs effects on the cardiovascular system could mitigate some of the complications of metabolic syndrome or diabetes

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Int J Mol Med 19:16572 Rushworth SA, Ogborne RM, Charalambos CA, OConnell MA (2006) Role of protein kinase C in curcumin-induced antioxidant response element-mediated gene expression in human monocytes