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In such a study (16-week randomized, double-blind, placebo-controlled), 204 individuals with obesity but not diabetes were treated with self-administered subcutaneous injections of pramlintide (nonforced dose escalation 240 g) or placebo three times a day, 15 minutes before meals without concomitant lifestyle intervention (200)

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As the novel multiple-active formulation was applied twice daily for only 7 days after one microneedling sitting in this study, it may be beneficial to explore the continued use of the formulation between monthly sittings