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Notably, cGAS- and BAX-dependent microglial senescence was exacerbated by the combined presence of the APOE4 allele and the TREM2 R47H variant, indicating both associated with increased risk and earlier onset of Alzheimer's disease and their potential role as upstream modulators of AD pathogenesis (Carling et al., 2024)

To evaluate whether LOsG induces ROS homeostasis disorder, a timely intraperitoneal injection of GSH (50 mg/kg/6 h) was made into animals challenged with LOsG as described above (LOsG.TdGSH group, n = 10)

2022 Apr 26;23(9):4783