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Surface modification methods, such as PEGylation or acetylation, are being used to balance bioactivity with biocompatibility to control these effects

Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease

Specifically, these problems are highlighted when targeting cytokine pathways

Lee et al., 2020

In vitro and animal studies in vivo have demonstrated the mechanisms of action of AGE, which involve its antioxidant, anti-inflammatory and modulatory effects on neurotransmitter function in the brain regions that are associated with the pathogenesis of AD