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The bioactive compounds within them can regulate inflammatory pathways by suppressing the production of pro-inflammatory cytokines and enzymes, such as tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) (11, 12)

doi:10.1186/s12902-021-00816-4

144,145,146,147 Precursors of neurotrophic factors also induce oligodendrocyte death

Later studies built on these findings by showing the ability of CAR T reg cells to prevent and/or ameliorate disease in other mouse models of colitis 99 , colitis-associated cancer 100 , and experimental autoimmune encephalomyelitis 101

Nanotoxicology Nanoecotoxicology 1, 99123