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For the B 12 bolus experiment, mice were administered 5 g vitamin B 12 (Sigma, V2876) dissolved in water by oral gavage on day 6 after the start of doxycycline treatment, and blood samples were taken by submandibular collection just before and 24 h after the bolus

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It contains inositol, choline, vitamin B6, vitamin B12, and methionine (a sulfa-free version without methionine is also available)

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