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Similarly, apolipoprotein A-IV, which is synthesized and secreted exclusively by the small intestine (primarily by the jejunum, but also by the duodenum and ileum), acts as a satiety factor that is downregulated by leptin (188) and upregulated by insulin and PYY in both rodents and humans (189)

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[DOI] [PubMed] [Google Scholar] 64.Godwin AK, Meister A, ODwyer PJ, Chin Shiou Huang, Hamilton TC, Anderson ME

Moreover, FAC treatment decreased GSH content but increased MDA levels in primary hepatocytes, indicating iron overload may induce ferroptosis