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Subacute/chronic axonal loss induced by vincristine also involves the SARM1-mediated axonal destruction pathway, and the genetic deletion of SARM1 blocks the development of bortezomib- and vincristine-induced CIPN in mice [65, 72]

49,50 Alternatively, dysregulation in redox modifications leads to aberrant redox signaling, in which hydrogen peroxide generated under physiological or pathological stimuli serves as a secondary messenger, closely linked to the cellular redox state

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Adhering to the right storage requirements can reduce the risk of degradation, which can help support the stability of the peptide and preserve analytical consistency, so that you achieve reliable results

George, A., Kaye, S