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Iron overload appears to induce an auto-toxic circuit resulting in neurodegeneration, but iron deficiency has also been implicated in neuronal death

(5322:) Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphatesynthetase I) (PRS-I) (PPRibP)

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Treatment with intra-tracheal administration of NAC on pulmonary edema formation induced by phosgene exposure in rabbit lungs lowered pulmonary artery pressure, lung weight gain, the concentration of peptide leukotrienes LTC 4 , D 4 , and E 4 , and lipid peroxidation which were increased following exposure to phosgene (84)