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Another neurological symptom is depression, due to the deficiency leading to higher levels of oxidative stress, DNA damage, and cell death

When the extracellular potassium concentration increases due to neuronal activity, astrocytes can sense and respond and help maintain the appropriate level of excitatory activity by regulating the distribution of ions

In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development (Strycharz-Dudziak et al., 2020), obesity (Rusetskaya et al., 2019), signal transduction, and inflammation (Rusetskaya et al., 2019)

In a family with PAIS associated with severe hypospadias, the length of the androgen receptor NH 2 -terminal poly-glutamine repeat has been reported to be shortened to only 12 glutamine residues (266)

Disrupting the gut microbiota with broad-spectrum antibiotics or depleting B2 cells pharmacologically mitigated atherosclerosis, emphasizing the role of B2 cells beyond lipid metabolism (123)