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Recently, it has been shown that docosahexaenoic acid supplementation in porcine oocytes during IVM can improve AMPK regulation, upregulate the relative expression of genes related to mitochondrial potential and lipid metabolism, increase the levels of fatty acids and lipid droplets in mature oocytes, and promote an increase in ATP synthesis, further improving mitochondrial function and lipid metabolism to enhance homeostasis of energy metabolism, thereby improving the quality of mature oocytes and enhancing the embryonic developmental potential of IVP embryos [101]

These salvage treatment options have a narrow therapeutic index in comparison to first- and second-line therapeutic agents and need close monitoring for adverse effects and therapeutic levels (Table 5)