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More recently, Weerapana and coworkers measured cysteine reactivity in mutant worms with altered lifespan, and identified 50 cysteines that were affected by insulin/insulin-like growth factor-1 (IGF-1) signaling 21

Exogenous antioxidantsdouble-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses