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Oxidative stress induces MPT by targeting specific cysteine residues of cyclophillin D, which results in mitochondrial depolarization, oxidative phosphorylation uncoupling, release of intra-mitochondrial ions and metabolic intermediates, mitochondrial swelling and decrease in ATP synthesis

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An extensively studied example is the induction of ferritinophagy, a selective form of autophagy that promotes the degradation of the iron storage protein ferritin in MEFs or pancreatic cancer cells, resulting in an increase in labile iron [77, 78]

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doi: 10.1016/S0304-3959(00)00458-9 40 ChenY-NLiK-CLiZShangG-WLiuDNLuZMet al

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