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Statements Author contributions HK: Writing review & editing, Writing original draft, Conceptualization

, Lima J

While hyperammonaemia is an important manifestation of PA, MMA and IVA, its clinical significance needs to be considered together with other abnormalities, such as acidosis, ketosis, and lactic acidaemia, as well as distinguishing it from the hyperammonaemia caused by urea cycle disorders (UCDs) [11], the main group of conditions from which OAs must be differentiated [3, 12, 13]

Each peptide targets different but complementary mechanisms, with KPV adding potent anti-inflammatory activity through NF-B inhibition

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