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As catabolic pathways of the above-mentioned substrates all converge on TCA [7], this process plays a central role in the production of energy molecules in cardiomyocytes as well as in the responsiveness of the energy molecule production machinery, which has to adapt quickly and continuously to heart energy demand

This, in turn, has been demonstrated to result in the up-regulation of PD-L1 expression, the reduction of CD4 and CD8 T-cell activation and tumor infiltration, and the promotion of the growth of pancreatic ductal adenocarcinoma (PDAC) cells [112]

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The peptide has also demonstrated interactions with the dopaminergic and serotonergic systems, with studies showing that BPC-157 can modulate the effects of dopamine-related agents in animal models and counteract some behavioural and neurochemical consequences of both dopamine agonists and antagonists (Sikiric et al., 2010)

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