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Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)

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When the pancreas does not produce proper amounts of insulin, or if cells cannot properly process insulin, this results in diabetes

The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase