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(1984) include a lack of doseresponse despite a large dose range (37.5300 mg/kg) and a lack of identification of the purity of the tested substance

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Cheap unbranded vials of unknown origin can cause severe allergic reactions, including Stevens-Johnson syndrome (a rare but serious skin reaction)

In this case, overall assessment (WoE) of the general biological plausibility and of the empirical support of KERs was considered as high for this AOP, as well as essentiality, once for this criterion the first four KEs that trigger the AO are also classified as such