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However, in aging, it is very common to find cases of incipient atherosclerosis, which leads to a reduction in blood flow and cerebral oxygen consumption (Bakker et al., 2014)

EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

S., Cancer Res., 1976, 36, 1744

Another study demonstrated that excessive heme oxygenase-1 (HO-1) production in microglia triggers harmful iron accumulation, which can be effectively controlled and corrected by iron chelators such as deferoxamine (DFX) (Fernndez-Mendvil et al., 2021)

Clinical characteristics of early-onset and late-onset leigh syndrome