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Unlike regular ascorbic acid, Ester-C is pH-neutral

this demonstrates that agonists at the glycine modulatory site on NMDARs significantly reduce negative, cognitive and positive symptoms in patients with schizophrenia on antipsychotic drugs

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Small-molecule drugs designed to modulate central nervous system pathways such as iron metabolism, antioxidant defense, or lipid peroxidation often affect analogous targets in the systemic circulation, disrupting normal peripheral organ function

The ability of DMF to downregulate NF-B signaling [36, 37] should not be involved either, as an increase in GST expression is expected following a pharmacological upregulation rather than downregulation of the NF-B pathway, as reported for GST pi [38]