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1 Introduction With an aging global population, it is estimated that 2.2 billion people worldwide are suffering from visual dysfunction, which severely impedes the individuals quality of life and poses threats to public health ( Ferroptosis, a term initially coined by Dixon in 2012, is a distinctive form of RCD featured by the iron-dependent lethal aggregation of lipid peroxides located at the cell membrane ( Figure 1 )

3.3.1 Central immune system: aberrant activation of microglia and astrocytes In EDC, aberrant microglial and astrocytic activation constitutes a central mechanism linking neuroinflammation to neural circuit dysfunction

L-Glutathione acts as a powerful antioxidant and detoxifying agent

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