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Apocynin is a bioactive phenol extracted from the roots of Apocynum venetum L., and as a NOX2 inhibitor, it can prevent ROS production and reduce inflammatory responses (Philippens et al., 2013)

Mitchell CJ, Churchward-Venne TA, Parise G, Bellamy L, Baker SK, Smith K, Atherton PJ, Phillips SM

The incubation of vonifimod with human hepatocytes resulted in the formation of nine metabolites, including hydroxy-vonifimod (M1 and M2), inactive carboxylic acids (M3 M6), active vonifimod-phosphate (M7), and M3 glucuronides (M3-G1 and M3-G2)

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In addition, demographic factors such as age, gender, duration of scars, type of acne scar, and Fitzpatrick skin type were found to influence treatment outcomes, highlighting the importance of patient-based approach in managing acne scars