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PRRs such as toll-like (TLRs), NOD-like (NLRs), RIG-1-like (RLRs), or C-type lectin receptors (CLRs) recognize pathogen-associated or (more generally) microbe-associated molecular patterns (PAMPs, MAMPs) like flaggelin, peptidoglycans, lipopeptides, lipopolysaccharides (LPS), and others (Mavris and Sansonetti, 2004