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ROS has also been reported to activate Akt by inhibiting phosphatase and tensin homolog deleted from chromosome 10 (PTEN), the phosphatase counteracting PI3K-dependent Akt activation [167]

The expression of CDO was able to reduce intracellular cysteine levels in HepG2/C3A cells, but the effect was dependent on the amount of extracellular cysteine to which the cultures were exposed