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Dr Juurlink suggests that any patient who meets the EXtracorporeal TReatments In Poisoning (ExTRIP) criteria for hemodialysis might be a candidate

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The mechanism of its pathogenesis is not fully understood, multiple parallel hits are believed to be involved, including insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors ( In recent years, more and more attention has been paid to intestinal flora and its metabolites

found that TMAO promoted calcium/phosphate-induced calcification in the vascular smooth muscle cells of rats and human urinary system patients in a dose-dependent manner, and upregulated the expression of bone-related molecules (Runt-related transcription factor2, Runx2, and Bone morphogenetic protein-2, BMP2)

In prostate cancer, the ox-LDL/lncRNA-DYNLRB2-2 circuit might be involved in the promotion of proliferation, migration and invasion rates (Wan et al., 2015)