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Blood pressure Both REDEFINE 1 and 2 reported reductions in systolic blood pressure

The study was designed to show that overall survival with pemetrexed was non-inferior to docetaxel, as the major efficacy outcome measure, and that overall survival was superior for patients randomized to pemetrexed compared to docetaxel, as a secondary outcome measure

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Critical for bone healing, less relevant for avascular cartilage but important for subchondral bone supporting cartilage

244 The PI3K/AKT signaling pathway The PI3K/AKT pathway is an important cell signaling pathway that plays a key role in regulating various biological processes, such as cell proliferation, apoptosis, and metabolism