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Eosinophil depletion (PHIL mice) led to increased colitis severity and stronger T helper 17 (Th17) responses, as well as increased production of TNF and IFN by CD4 + T cells ( + and CD80 + ) with single-cell transcriptomics, which are induced by cytokines such as IL-33 and IFN and exhibit bactericidal and T cell regulatory functions in DSS-colitis

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H 2 S activates Nrf2 by S-sulfhydrating Kelch-like ECH-associated protein 1 (Keap1), which releases Nrf2 from repression, thereby mitigating oxidative stress (Hourihan et al., 2013)