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In failing human hearts, reduced NRF1/2 activity is associated with diminished mitochondrial biogenesis and respiratory chain defects

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B12 ensures that the body produces an adequate supply of red blood cells, which are responsible for delivering oxygen to tissues and organs

4.1.3 Mice and in vivo experiments All animal experiments were approved by The Institute of Cancer Research Animal Welfare and Ethical Review Body and performed in accordance with the UK Home Office Animals (Scientific Procedures) Act 1986, the UK National Cancer Research Institute guidelines for the welfare of animals in cancer research and the ARRIVE (animal research: reporting in-vivo experiments) guidelines