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However, proliferation was elevated solely under rotational stress and was inhibited in the combined model

A rational method of prioritizing drugs and drug targets with a metabolic network as an underlying framework also provides for a possible mechanism of action for many of the drugs selected (e.g., the network model enables the analysis of what biosynthetic pathways are inhibited when a particular enzyme's function is pharmacologically inhibited)

A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation

IRF3 inhibits nuclear translocation of NF-B to prevent viral inflammation

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