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Cystine-Glutamate Transporter SLC7A11 in Cancer Chemosensitivity and Chemoresistance

Melatonin Melatonin, a hormone synthesized primarily by the pineal gland and locally in skin cells, plays a critical role in protecting melanocytes from oxidative stress by acting as a potent antioxidant and modulating cellular defense mechanisms 196

This process is mediated by glutaredoxins (GLRXs, also known as GRXs), which catalyze both glutathionylation and deglutathionylation, as well as by sulfiredoxins (SRXs) 9,10

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The discomfort typically presents as mild cramping or a sensation of fullness in the upper abdomen