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Vitamins, carotenoids, polyphenols, melatonin, caffeine, N-acetylcarnosine and N-acetylcysteine are strong antioxidants that target oxidative stress in the pathogenesis of cataracts (19,28,107,118,132,145,176)

Topical formulations require penetration enhancers or vehicle optimization, and in vivo data suggest lower bioavailability compared to subcutaneous administration

The development of more potent and selective glutaminase inhibitors and effective delivery strategies remains an active area of research

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The hypothalamus releases growth hormone-releasing hormone (GHRH) and, oppositely, somatostatin, which respectively stimulate and inhibit the pituitary