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One study recognized a dose of up to three grams per day as generally safe (4)

OShea JJ, Schwartz DM, Villarino AV et al (2015) The JAK-STAT pathway: impact on human disease and therapeutic intervention

Loss of GPX4 leads to uncontrolled lipid peroxidation with the highest levels of lipid peroxidation in immature reticulocytes when both GPX4 and vitamin E (known to antagonize peroxide production) were deficient ( LC3 lipidation