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In PD, progressive degeneration of dopaminergic neurons disrupts this delicate balance, reducing striatal dopamine levels and impairing the direct and indirect pathways

Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells

G.DelattreJ

each R46, R47, R48 and R49 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted alkyl, arylalkyl, substituted alkyl, eye lo alkyl, substituted alkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, hetero arylalkyl, substituted hetero arylalkyl, -NR50R51, -C(O)R50 or -S(O)2R50 or optionally R50 and R51 together with the atom to which they are both attached form a cycloheteroalkyl or substituted cycloheteroalkyl ring

32,33 Acetyl-L-carnitine in chemotherapy induced neuropathy Clinical studies tested the neuroprotective effect of ALC in chemotherapy-induced neuropathy but no data about neuropathic pain reduction are available