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Senescent cells promote tissue NAD + decline during ageing via the activation of CD38 + macrophages

The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function

High expression levels of haem oxygenase-1 promote ferroptosis in macrophage-derived foam cells and exacerbate plaque instability

Its favorable effects in preclinical PD models (including improvements in motor coordination and neuronal survival) support the idea that resveratrol or resveratrol-rich diets could be beneficial in PD, although clinical studies are needed to confirm its efficacy and optimal dosing

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