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Moreover, Circadian genes also regulate angiogenesis by influencing endothelial and pericyte functions, through mechanisms such as modulation of angiogenic factors (38), basement membrane degradation (39), extracellular matrix remodeling (40), and regulation of endothelial migration, proliferation, and pericyte recruitment (41)

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Conclusion Across topical and tissue models, GHK-Cu is studied for potential roles in matrix support, wound-area remodeling signals, oxidative balance, and inflammation moderation

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