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All cryo-EM data were collected on a Titan Krios 300 kV microscope (Thermo Fisher Scientific) equipped with a GIF-Quantum energy filter (Gatan) with the slit set to 20 eV and a Gatan K3 Summit direct electron detection camera (Gatan) at Case Western Reserve University

Ideal candidates are research models with metabolic dysfunction characterized by both impaired insulin sensitivity and elevated adipose tissue NNMT expression common in diet-induced obesity, age-related metabolic decline, and type 2 diabetes models

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The fine quality needle, sharp with grinding and silicone coating, improves patient comfort

You will notice younger-looking skin with consistent use