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Glutathione Metabolism and Its Implications for Health.Am

Phenytoin accelerates metabolism of vit.D3 and lead to osteomalacia Therapeutic benefits: To treat neonatal jaundice - phenobarbitone can be given to infant soon after birth to induce hepatic glucuronyltransferase (Bilirubin is conjugated and excreted) - In Cushings syndrome (Abnormally high levels of cortisol) phenytoin may reduce the manifestations by enhancing degradation of steroids Chronic poisoning : faster metabolism of accumulated poisonous substance Vegetables like cabbage ,spinach etc can induce microsomal enzymes and promotes the rapid elimination of the drugs ENZYME INHIBITION Certain drug substrates inhibit cytochrome P450 enzyme activity cimetidine and ketoconazole bind tightly to the P450 heme iron reduce the metabolism of endogenous substances competitive inhibition

P.MendesC.et al

9595 - 9601, Journal articles | 2024 Sims M

More recently, they have been proposed as a possible mechanism in the prevention and/or therapy of MetS or disorders afflicting the central nervous system due to their anti-inflammatory effects